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Sascha Patz



WSI-Algorithms in Bioinformatics
Sand 14, Office C324a
D-72076 Tübingen

Phone:  +49-7071-29-70453
Fax:      +49-7071-29-5148
E-Mail:  sascha.patz at

Research Topics:

  • Synthetic microbiomes
  • Metagenomic analysis of plants, seeds (ancient), soil, humans and bioreactors
  • Microbial functional analysis
  • Comparative genomics of bacteria (e.g. plant growth-promoting bacteria: PGPB)
Main Collaborations:

  • Bioreactor metagenomic analysis & assembly related to waste water digestion.
Environmental Biotechnology (Univ. of Tübingen): Prof. Dr. Lars Angenent 

  • Bio-inoculant mediated shift of microbial communities and its functional traits.
Leibniz Institute of Vegetable and Ornamental Crops Großbeeren: Dr. rer. nat. habil. Silke Ruppel, Dr. Matthias Becker, Dr. Burkhardt Flemer 

  • Comparative genomics of Kosakonia radicincitans DSM16656(T) among PGPB and pathogens.
"Julius Kühn-Institut" - Federal Research Centre for Cultivated Plants Braunschweig: Dr. Beatrice Berger, Dr. Yvonne Becker

  • Enhancing the restoration of the gut microbiome after antibiotic treatment.
University fo Antwerp: Basil Britto Xavier



[01] Patz, S.; Witzel, K.; Ruppel, S. Culture Dependent and Independent Analysis of Potential Probiotic Bacterial Genera and Species Present in the Phyllosphere of Raw Eaten Produce. Int. J. Mol. Sci. 2019

[02] Patz, S.; Becker, Y.; Richert-Pöggeler, KR.; Berger, B.; Ruppel, S.; Huson, DH.; Becker, M. Phage tail-like particles are versatile bacterial nanomachines: A mini-review. J. Adv. Res. 2019

[03] Hrynkiewicz, K.; Patz, S.Ruppel, S. Salicornia europaea L. as an underutilized saline-tolerant plant inhabited by endophytic diazotrophs. J. Adv. Res. 2019 (Phylogenetics, Visulaization)

[04] Sarhan, MS.; Hamza, MA.; Youssef, HH.; Patz, S.Becker, M.; ElSawey, H.; Nemr, R.; Daanaa, HA.; Mourad, EF.; Morsi, AT.; Abdelfadeel, MR.; Abbas, MT.; Fayez, M.; Ruppel, S.; Hegazi, NA. Culturomics of the plant microbiome and the dawn of plant-based culture media. J. Adv. Res. 2019 (Bioinformatics Sections)


[05] Hegazi, NA.; Sarhan, MS.; Fayez, M.; Patz, S.; Ruppel, S.; Murphy, BR. G3 PhyloChip Analysis Confirms the Promise of Plant-Based Culture Media for Unlocking the Composition and Diversity of the Maize Root Microbiome and for Recovering Unculturable Candidate Divisions/Phyla. Microbes Environ. Vol. 33, No. 3, 317-325. 2018 (Bioinformatics Support)

[06] Becker, M.; Patz, S.; Becker, Y.; Berger, B.; Drungowski, M.; Bunk, B.; Overmann, J.; Spröer, C.; Reetz, J.; Tchuisseu Tchakounté, GV.; Ruppel. , S. Comparative Genomics Reveal a Flagellar System, a Type VI Secretion System and Plant Growth-Promoting Gene Clusters Unique to the Endophytic Bacterium Kosakonia radicincitans. Front. Microbiol. 9,1997. 2018 (Comparative Genomics, Phylogeny, Data Acquisition & Processing, Visualization)

[07] Tchuisseu Tchakounté, GV.; Berger, B.; Patz, S.; Henri, F.; Ruppel, S. Community structure and plant growth-promoting potential of cultivable bacteria isolated from Cameroon soil. Microbiological Research. 2018 (Phylogenetics, Microbiome Analysis, Data Processing)

[08] Berger, B.; Patz, S.; Ruppel, S.; Dietel, K.; Faetke, S.; Junge, H.; Becker, M. Successful formulation and application of plant growth-promoting Kosakonia radicincitans in maize cultivation. BioMed Research International, Article ID 6439481. 2018. (Data Acquisition & Processing)


[09] Ekandjo, L.K.; Ruppel, S.; Remus, R.; Witzel, K.; Patz, S.; Becker, Y. Site-directed mutagenesis to deactivate two nitrogenase isozymes of Kosakonia radicincitans DSM16656T. Canadian Journal of Microbiology 64, 97-106. 2017. (Comparative Genomics, Structural Bioinformatics, Visualization)


[10] Hegazi, NA.; Sarhan, MS.; Fayez, M.; Patz, S.; Ruppel, S.; Murphy, BR. Plant-fed Versus Chemicals-fed Rhizobacteria: Plant-only-teabags Culture Media not only Increase Culturability of Rhizobacteria but also Unveil the Not-yet-Cultured Lysobacter sp., Novosphingobium sp. and Pedobacter sp. PLOS ONE. 2016. (Phylogeny, Phylochip Analysis, Methodology, Software, Writing) 

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